Van de Ven Brace Ends The Toffees' Run at New Stadium
The Dutch defender emerged as the initial backline player to net two goals in a Premier League match for Tottenham since Jan Vertonghen in March 2013.
At a glance
Micky Van de Ven heads home twice in opening period
Everton's defender has equalizer ruled after VAR review
Pape Matar Sarr nets final goal in dying moments
The defeat is Everton's initial at their new ground
The Tottenham defender scored twice as Spurs prolonged their winning streak in away games in the top division and delivered Everton their initial loss at Hill Dickinson Stadium.
The Toffees were unbeaten in their last five matches at their recently opened stadium at the dockside location, having left their historic home behind after more than a century at the end of last season.
But Tottenham's leader Van de Ven pounced on two occasions from corners in the first half to put their impressive record at jeopardy, and they were unable to turn it around before Pape Matar Sarr - assisted by former Toffees attacker Richarlison - headed home a third to put the game to bed.
Jake O'Brien thought he had levelled the tally a short while after Van de Ven's first goal, directing a bullet header past the Spurs keeper from an Everton corner.
Beto, in the meantime, missed a number of opportunities, while Vicario made a series of fine saves to ensure the London club went five matches on the road unbeaten in the Premier League.
But the VAR intervened, advising Craig Pawson to review the score on the screen and the official decided that the winger and Iliman Ndiaye were in offside positions and had interfered with the Tottenham goalkeeper.
This victory moves Thomas Frank's side up to third in the Premier League, five points off local foes and leaders Arsenal.
Everton remain 14th and sit six points clear of the drop zone.
Spurs breakdown: The defender fulfils role at both ends of the field
Following a drab weekday display in the European competition against the French side, where they managed a only two shots on goal, Frank opted for Randal Kolo Muani in attack instead of former Toffees player Richarlison.
The new arrival was failed to make much of an impact before being substituted for the substitute after 60 minutes on the pitch, but it turns out he proved unnecessary in the final outcome.
Centre-back Van de Ven converted into an offensive threat to be reckoned with.
Tottenham's opening strike came from a well-worked corner routine, with Rodrigo Bentancur heading the ball back across the face of goal for an free Van de Ven to score.
And Ven de Ven - stepping up as captain in Cristian Romero's unavailability - notched his next goal in first-half stoppage time as he outjumped Jordan Pickford to nod in.
Van de Ven was equally outstanding in defensive duties, partnering effectively with his defensive colleague as the duo handled superbly with the numerous deliveries thrown their way by the opposition.
Toffees breakdown: Everton lacking finishing touch
Everton's recent stadium had been a fortress, but it seems the novelty may have worn off somewhat and fans flocked to the exits after the midfielder's third for Spurs.
The break in Everton's unbeaten home run won't be a massive concern for David Moyes, but their attacking woes are.
The forward and Thierno Barry - the Everton's pair of recognised strikers - had netted just a single goal combined before the weekend's outing.
And they were unable to add to that miserable record on a damp and dreary night on in Liverpool.
Beto's form was epitomized when he opted to overhead kick a clear chance from near the goal, even with having space and time to readjust for a more conventional shot that would have challenged Vicario.
The substitute, too, was unable to make an impact after coming on for the starter in the 65th minute.
It wasn't for a lack of chance. The majority of the home side's attacks came through Grealish and the forward, who relentlessly whipped threatening balls into the Tottenham box.
Upcoming fixtures for these two sides?
Everton: The team head to the Stadium of Light in the top flight on early November at 20:00 GMT.
Tottenham: The London club go to St James' Park on Wednesday, 29 October for their fourth-round Carabao Cup match against Newcastle.